Oakwood has an aseptic process for manufacturing polymer-based biodegradable microspheres for the sustained release of pharmaceuticals. Levitronix^® pumps and flow meters are utilized in various aspects of our continuous manufacturing process. An overview of Oakwood’s microsphere manufacturing process will be presented with several examples of different sustained release formulations. The impact of switching from traditional peristaltic pumps to Levitronix^® pumps will be discussed.